Natural Product Hybrids
نویسنده
چکیده
this review highlights several classes of natural product hybrids. First, structural hybrids emanating from different biosynthetic pathways exemplified by the polyketide peptide alkaloid anachelin are discussed. Another class is the so-called functional hybrids, where different functions of natural products are hybridized. the conjugate between nostocarboline and the well-known antibacterial agent ciprofloxacin displays a very broad spectrum of activity combining photosynthesis and gyrase-inhibiting activity. Last, higher order hybrids are discussed. We present the ternary hybrid of titanium dioxide, the anachelin chromophore and poly-ethyleneglycol (pEG). this chimera allows for the functionalization of tio2 surfaces to render those protein resistant. this article thus shows how natural products can be hybridized to generate compounds with unprecedented bioactivity thus enabling the development of novel drugs and advanced materials.
منابع مشابه
Synthesis of spiroacetal-nucleosides as privileged natural product-like scaffolds.
The elaboration of a 6,6-spiroacetal scaffold to incorporate a nucleoside unit at the anomeric position is described. The novel spiroacetal-nucleoside hybrids were generated via nucleosidation of acetoxy-spiroacetal with a series of silylated nucleobases under Vorbrüggen conditions.
متن کاملBioinspired, releasable quorum sensing modulators.
We demonstrate the synthesis and immobilization of natural product hybrids featuring an acyl-homoserine lactone and a nitrodopamine onto biocompatible TiO(2) surfaces through an operationally simple dip-and-rinse procedure. The resulting immobilized hybrids were shown to be powerful quorum sensing (QS) activators in Pseudomonas strains acting by slow release from the surface.
متن کاملMolecular characterization of new natural hybrids of Saccharomyces cerevisiae and S. kudriavzevii in brewing.
We analyzed 24 beer strains from different origins by using PCR-restriction fragment length polymorphism analysis of different gene regions, and six new Saccharomyces cerevisiae x Saccharomyces kudriavzevii hybrid strains were found. This is the first time that the presence in brewing of this new type of hybrid has been demonstrated. From the comparative molecular analysis of these natural hybr...
متن کاملQuinone-annonaceous acetogenins: synthesis and complex I inhibition studies of a new class of natural product hybrids.
The natural product hybrids quinone-mucocin and quinone- squamocin D were synthesized. In these hybrids, the butenolide unit of the annonaceous acetogenins mucocin and squamocin D is exchanged for the quinone moiety of the natural complex I substrate ubiquinone. For both syntheses, a modular, highly convergent approach was applied. Quinone-mucocin was constructed out of a tetrahydropyran (THP) ...
متن کامل